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neoadjuvant therapy
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breast cancer staging and (1)
chemoradiation and (1)
colorectal cancer and (1)
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follicular lymphoma and (2)
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plasma cell neoplasms and (2)
prostate cancer (1)
radiation therapy (1)
rectal cancer and (3)
rectal surgery and (1)
stage iii non-small-cell lung cancer and (2)
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Principles & Practice of Lung Cancer
Chapter 55. Preoperative Chemotherapy/Radiation Therapy for Early Stage and Locally Advanced Non–Small Cell Lung Carcinoma
Principles & Practice of Lung Cancer
Chapter 48. Antiangiogenic Agents >
Bevacizumab in the Neoadjuvant Setting
Three trials are evaluating the potential of bevacizumab in the neoadjuvant setting. If effective, this approach may reduce tumor burden and either facilitate or negate the need for resection. The ...
Principles & Practice of Lung Cancer
Chapter 55. Preoperative Chemotherapy/Radiation Therapy for Early Stage and Locally Advanced Non–Small Cell Lung Carcinoma >
Induction Therapy for Locally Advanced Lung Cancer (Stages IIIA and IIIB)
Principles & Practice of Lung Cancer
Chapter 55. Preoperative Chemotherapy/Radiation Therapy for Early Stage and Locally Advanced Non–Small Cell Lung Carcinoma >
Treatment-Related Morbidity and Mortality in Combined Modality Induction Trials
The morbidity from combined modality therapy that includes surgery is not insignificant. It is often difficult to attribute a particular toxicity to just one modality because the entire “package” affects ...
Principles & Practice of Lung Cancer
Chapter 55. Preoperative Chemotherapy/Radiation Therapy for Early Stage and Locally Advanced Non–Small Cell Lung Carcinoma >
Second-Generation Phase II Studies of Induction Chemoradiotherapy before Surgery
Cancer: Principles & Practice of Oncology
Chapter 72. Treatment of Head and Neck Cancer >
Preoperative Radiation Therapy
Preoperative RT should be considered for the following situations: (1) fixed neck nodes, (2) initiation of postoperative RT will be delayed more than 8 weeks, (3) use of the gastric ...
Cancer: Principles & Practice of Oncology
Chapter 82. Cancer of the Pancreas >
An Alterative Approach to Resectable Disease: Preoperative Therapy
(updated 4/26/2012)
Some groups have investigated preoperative therapy, typically with chemoradiation (Table 82.7). Preoperative therapy has sound rationale: (1) initiation of local and systemic therapy shortly after diagnosis rather than weeks following ...
Cancer: Principles & Practice of Oncology
Chapter 86. Cancer of the Small Intestine >
Adjuvant and Neoadjuvant Therapy
The recurrence pattern for small bowel adenocarcinoma is mainly systemic.72,83 – 85 Duodenal adenocarcinoma, although having a higher local failure rate compared to jejunal or ileal adenocarcinoma, also recurs in a predominately ...
Cancer: Principles & Practice of Oncology
Chapter 90. Cancer of the Rectum >
Preoperative Radiation Therapy
(updated 2/7/2013)
The second issue of importance is whether adjuvant therapy should be given preoperatively or postoperatively and the exact timing of the chemotherapy. Current data clearly favor the preoperative approach. ...
Cancer: Principles & Practice of Oncology
Chapter 119. Cutaneous Melanoma >
Neoadjuvant Therapy for Resectable Stage III or IV Melanoma
Neoadjuvant therapy for resectable stage III or stage IV melanoma remains an investigational approach. Unlike breast and rectal cancer, for which chemotherapy regimens are associated with clinical downstaging and pathologic ...
Cancer: Principles & Practice of Oncology
Chapter 127. Non-Hodgkin Lymphomas >
Rituximab as Initial Induction Therapy
(updated 3/26/2012)
Because of the toxicity of chemotherapy and interferon, investigators have examined the role of monoclonal antibody therapy as initial treatment for patients with follicular NHL. A phase 2 study treated ...
Cancer: Principles & Practice of Oncology
Chapter 127. Non-Hodgkin Lymphomas >
Chemotherapy-Biologic Combinations as Initial Induction Therapy
The highest response rates in FL have been observed with the addition of the monoclonal antibody rituximab to chemotherapy combinations as an initial treatment strategy. A small phase 2 study ...
Cancer: Principles & Practice of Oncology
Chapter 136. Plasma Cell Neoplasms >
Induction Therapy in Newly Diagnosed Patient
Decision about the induction regimen in newly diagnosed MM is partly influenced by whether or not the patient is a transplant candidate. Mainly, alkylating agents should be avoided in patients ...
Cancer: Principles & Practice of Oncology
Chapter 138. Benign and Malignant Mesothelioma >
Induction Chemotherapy Followed by Surgery
Induction or neoadjuvant therapy for pleural mesothelioma followed by surgery has been patterned after the use of such therapy with non–small cell lung cancer. With the improved efficacy of doublet ...
Perez and Brady’s Principles and Practice of Radiation Oncology
Chapter 39. Nasal Cavity and Paranasal Sinuses >
Chemotherapy—Neoadjuvant and Concomitant
Neoadjuvant chemotherapy is sometimes offered in order to reduce tumor volume, which may permit removal of tumor with a less morbid resection or facilitate radiotherapy planning if shrinkage pulls away ...
Perez and Brady’s Principles and Practice of Radiation Oncology
Chapter 48. Lung >
Neoadjuvant (Induction) Treatment
Perez and Brady’s Principles and Practice of Radiation Oncology
Chapter 56. Cancer of the Pancreas >
Neoadjuvant Therapy
Even after undergoing curative resection for pancreatic cancer, 80% to 85% of patients will recur. In addition, positive margins or nodal disease increases this rate of recurrence to 90% (8,96). ...
Perez and Brady’s Principles and Practice of Radiation Oncology
Chapter 58. Colon and Rectum >
Neoadjuvant Therapy
Considerable debate has evolved regarding the optimal approach to adjuvant therapy in rectal cancer. Although both preand postoperative adjuvant therapy can be effective, there has been a significant recent trend ...
Perez and Brady’s Principles and Practice of Radiation Oncology
Chapter 58. Colon and Rectum >
Neoadjuvant Chemoradiation
The improvement in outcomes with combined chemoradiation and postoperative adjuvant therapy has led to similar recent approaches in the neoadjuvant therapy of this disease. In the United States this has ...
Principles and Practice of Surgical Oncology
Chapter 25. Adjuvant Therapy for Melanoma: Review of Published Data and Studies in Progress >
Preoperative (Neoadjuvant) Chemoimmunotherapy
Preoperative chemotherapy has become commonplace in the treatment of some tumor types, but has not found widespread application in melanoma. Nonetheless, patients with bulky nodal disease, resectable metastatic disease, and ...
Principles and Practice of Surgical Oncology
Chapter 32. Neoadjuvant Therapy for Esophageal Cancer >
Neoadjuvant Cancer Therapy
A working definition of neoadjuvant treatment of solid tumors, its goals, and a brief survey of its application in other solid tumors will lay the foundation for this chapter regarding ...
Principles and Practice of Surgical Oncology
Chapter 32. Neoadjuvant Therapy for Esophageal Cancer >
Neoadjuvant Therapy for Esophageal Cancer
The need for upgrading the standard of care for patients with esophageal cancer was clearly and effectively stated, perhaps understated, by two articles in the British Journal of Surgery in ...
Principles and Practice of Surgical Oncology
Chapter 34. Gastric Cancer: Perioperative Adjunctive Therapy >
Principles of Adjuvant and Neoadjuvant Therapy
The scientific principles underlying current protocols for adjuvant and neoadjuvant chemotherapy in connection with the surgical management of various solid tumors derive substantially from the experimental work of Skipper (1), ...
Principles and Practice of Surgical Oncology
Chapter 34. Gastric Cancer: Perioperative Adjunctive Therapy >
Neoadjuvant Therapy
Various preoperative treatment strategies have been studied with the goal of improving survival by downstaging the primary gastric tumor, thereby increasing the likelihood of achieving complete surgical resection with clear ...
Principles and Practice of Surgical Oncology
Chapter 36. Cancer of the Pancreas: Adjuvant and Neoadjuvant Therapy >
Neoadjuvant Therapy
In many of the trials of adjuvant therapy, a significant proportion of patients initially enrolled failed to complete their adjuvant protocol or experienced treatment commencement delays. Prolonged postoperative course and/or ...
Principles and Practice of Surgical Oncology
Chapter 39. Sphincter-Preserving Surgery in the Management of Rectal Cancer >
Neoadjuvant Chemoradiotherapy versus Radiotherapy Alone
In phase 2 studies comparing neoadjuvant chemoradiotherapy versus RT, rates of complete pathologic response are higher following preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy than they are in series using moderate- to high-dose ...
Principles and Practice of Surgical Oncology
Chapter 40. Colorectal Cancer: Adjuvant and Neoadjuvant Therapy >
Neoadjuvant Therapy: General Considerations
The term neoadjuvant therapy, as applied to colorectal cancer, would indicate the use of treatment (usually chemotherapy and/or radiation therapy) prior to definitive surgery. As with adjuvant therapy (which may ...
Principles and Practice of Surgical Oncology
Chapter 40. Colorectal Cancer: Adjuvant and Neoadjuvant Therapy >
Adjuvant and Neoadjuvant Radiation Therapy
Adjuvant radiation therapy by itself, either preoperative (neoadjuvant) (130–132), postoperative (133,134), or both (“sandwich technique”) is of value in decreasing local recurrence rate by roughly 20% to 50%. Many studies ...
Principles and Practice of Surgical Oncology
Chapter 40. Colorectal Cancer: Adjuvant and Neoadjuvant Therapy >
Neoadjuvant Therapy
Preoperative therapy, with radiation plus or minus chemotherapy, has conceptual appeal in the treatment of rectal carcinoma. Radiation prior to surgery should be less toxic to the small bowel, as ...
Principles and Practice of Surgical Oncology
Chapter 43. Gastrointestinal Stromal Tumors >
Neoadjuvant and Adjuvant Therapy for Primary Disease
Although patients with resectable disease should undergo surgery, single-institution retrospective series have demonstrated that recurrence rates are still high. In patients undergoing R0 or R1 resections, 5-year overall survival (OS) ...
Principles and Practice of Surgical Oncology
Chapter 51. Surgical Management of Primary Lung Cancer >
Neoadjuvant Therapy
In two randomized, prospective studies, neoadjuvant treatment has now been shown to improve survival for patients with stage III NSCLC (31,32). These studies used chemotherapy alone. There are phase 2 ...
Human Radiation Injury
Chapter 11. Toxicity Due to Total Body Irradiation >
Acute Toxicities of TBI for HCT
Acute toxicities may develop within hours or a few days after TBI. These are usually the result of edema, parenchymal cell loss, and/or inflammation. The most common acute side effects ...
Perry’s The Chemotherapy Source Book, 5e
Chapter 35. Chemotherapy of Genitourinary Cancer >
Neoadjuvant and Adjuvant Therapy in Localized and Locally Advanced Prostate Cancer
Although the rate of disease-free and overall survival (OS) is relatively high with both radical prostatectomy and radiation as primary therapy, special consideration must be given to the reality that ...
Perry’s The Chemotherapy Source Book, 5e
Chapter 47. Chemotherapy of Multiple Myeloma >
Initial Therapy for Transplant Eligible Patients
Eligibility for ASCT varies from country to country. In general, ASCT is offered to patients <65 years of age, whereas in the United States decisions are made depending upon “physiologic ...
Principles and Practice of Gynecologic Oncology
Chapter 15. Principles of Chemotherapy in Gynecologic Cancer > Choice of Specific Chemotherapeutic Regimens
Neoadjuvant
chemotherapy generally refers to the use of... ...
Principles and Practice of Gynecologic Oncology
Chapter 20. Vulva > Treating Locally Advanced Disease in the Vulva
Although the published experiences with preoperative singlemodality radiation therapy are ...
Diseases of the Breast
Chapter 35. Staging of Breast Cancer > Introduction
The AJCC system is both a clinical and pathologic staging ...
Diseases of the Breast
Chapter 48. Adjuvant Systemic Therapy: Endocrine Therapy > Historical Perspective and Rationale
Adjuvant systemic therapy
is defined as the... ...
Principles and Practice of Surgical Oncology
Chapter 32. Neoadjuvant Therapy for Esophageal Cancer > Neoadjuvant Cancer Therapy
Neoadjuvant cancer therapy is an additional treatment administered
... ...
Principles and Practice of Surgical Oncology
Chapter 52. Adjuvant Chemotherapy for Early-Stage Non-Small Cell Lung Cancer > Commentary
Available data indicate that >90% of patients who receive neoadjuvant ...
Human Radiation Injury
Chapter 10. Toxicity Due to Systemic Radiotherapy > 131I, 32P, and 166HO Therapy for the Treatment of Solid Tumors, Polycythemia Vera, and Multiple Myeloma
166
Ho-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-... ...
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More Results
Journal Results from PubMed
Hospital and surgeon volume in relation to survival after esophageal cancer surgery in a population-based study.
J. Clin. Oncol. | Feb 11, 2013
Neoadjuvant treatment of a solitary melanoma brain metastasis with vemurafenib.
J. Clin. Oncol. | Jan 21, 2013
Unresectable locally advanced pancreatic cancer: treatment with neoadjuvant leucovorin, fluorouracil, irinotecan, and oxaliplatin and assessment of surgical resectability.
J. Clin. Oncol. | Jan 21, 2013
Advocates' perspective: neoadjuvant chemotherapy for breast cancer.
J. Clin. Oncol. | Dec 18, 2012
Adaptive trials in the neoadjuvant setting: a model to safely tailor care while accelerating drug development.
J. Clin. Oncol. | Dec 18, 2012
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